Drug combination: Sertivan & Pregabalin alkem & Ibalgin 400 & Diclofenac al 25

Compared drugs
Sertivan (sertraline)
Pregabalin alkem (pregabalin)
Ibalgin 400 (ibuprofen)
Diclofenac al 25 (diclofenac)
Drug Interaction
Sertivan & Pregabalin alkem
The risk or severity of adverse effects can be increased when Pregabalin is combined with Sertraline.

Sertivan & Ibalgin 400
The metabolism of Ibuprofen can be decreased when combined with Sertraline.

Sertivan & Diclofenac al 25
The metabolism of Diclofenac can be decreased when combined with Sertraline.

Ibalgin 400 & Diclofenac al 25
The risk or severity of adverse effects can be increased when Diclofenac is combined with Ibuprofen.

Food interactions and other recommendations

Sertivan: Avoid alcohol. Avoid St.John's Wort. Avoid taking with grapefruit juice. Take with food.
Pregabalin alkem: Avoid alcohol (may increase CNS effects). When taken with food, Cmax decreases, while Tmax is prolonged. Despite these observations, the total absorption of pregabalin is not effected to a clinically relevant degree. Pregabalin can be taken with or without food.
Ibalgin 400: Avoid alcohol Food delays the time to reach peak plasma concentrations by 30-60 minutes and reduces peak plasma concentrations by 30-50%. Extent of absorption is unaffected. Take with food to reduce gastric irritation.
Diclofenac al 25: Avoid alcohol. Take with food to reduce irritation.
 
Combination of side effects
Combination of common side effects of all medicines
Constipation
Sertivan (uncommon)
Pregabalin alkem (very common)
Ibalgin 400 (very common)
Diclofenac al 25 (common)

Diarrhea
Sertivan (uncommon)
Pregabalin alkem (common)
Ibalgin 400 (common)
Diclofenac al 25 (common)

Dizziness
Sertivan (uncommon)
Pregabalin alkem (very common)
Ibalgin 400 (very common)
Diclofenac al 25 (uncommon)

Edema
Sertivan (uncommon)
Pregabalin alkem (common)
Ibalgin 400 (common)
Diclofenac al 25 (common)

Flatulence
Sertivan (common)
Pregabalin alkem (common)
Ibalgin 400 (very common)
Diclofenac al 25 (common)

Headache
Sertivan (uncommon)
Pregabalin alkem (very common)
Ibalgin 400 (very common)
Diclofenac al 25 (uncommon)

Nausea
Sertivan (uncommon)
Pregabalin alkem (very common)
Ibalgin 400 (very common)
Diclofenac al 25 (common)

Itching
Sertivan (common)
Pregabalin alkem (common)
Ibalgin 400 (uncommon)
Diclofenac al 25 (uncommon)

Vomiting
Sertivan (common)
Pregabalin alkem (common)
Ibalgin 400 (very common)
Diclofenac al 25 (common)

Somnolence
Sertivan (uncommon)
Pregabalin alkem (very common)
Ibalgin 400 (very common)
Diclofenac al 25 (uncommon)


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