Drug combination: Simvastatin-ratiopharm & Agen 10
Drug InteractionSimvastatin-ratiopharm & Agen 10
The serum concentration of Simvastatin can be increased when it is combined with Amlodipine.
Food interactions and other recommendationsSimvastatin-ratiopharm: Avoid alcohol. Avoid drastic changes in dietary habit. Avoid taking with grapefruit juice.
Agen 10: Avoid natural licorice. Grapefruit down regulates post-translational expression of CYP3A4, the major metabolizing enzyme of amlodipine. Grapefruit, in all forms (e.g. whole fruit, juice and rind), can significantly increase serum levels of amlodipine and may cause toxicity. Avoid grapefruit products while on this medication. Take without regard to meals.
Combination of side effects Combination of common side effects of all medicinesAbdominal Pain
Simvastatin-ratiopharm (uncommon)
Agen 10 (common)
Edema
Simvastatin-ratiopharm (common)
Agen 10 (common)
Headache
Simvastatin-ratiopharm (uncommon)
Agen 10 (common)
Nausea
Simvastatin-ratiopharm (uncommon)
Agen 10 (common)
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