Drug combination: Lyrica & Ibalgin 400 & Sertivan

Compared drugs
Lyrica (pregabalin)
Ibalgin 400 (ibuprofen)
Sertivan (sertraline)

Drug Interaction

Lyrica & Sertivan
The risk or severity of adverse effects can be increased when Pregabalin is combined with Sertraline.

Ibalgin 400 & Sertivan
The metabolism of Ibuprofen can be decreased when combined with Sertraline.

Food interactions and other recommendations

Lyrica: Avoid alcohol (may increase CNS effects). When taken with food, Cmax decreases, while Tmax is prolonged. Despite these observations, the total absorption of pregabalin is not effected to a clinically relevant degree. Pregabalin can be taken with or without food.
Ibalgin 400: Avoid alcohol Food delays the time to reach peak plasma concentrations by 30-60 minutes and reduces peak plasma concentrations by 30-50%. Extent of absorption is unaffected. Take with food to reduce gastric irritation.
Sertivan: Avoid alcohol. Avoid St.John's Wort. Avoid taking with grapefruit juice. Take with food.

Combination of side effects

Combination of common side effects of all medicines

Constipation
Lyrica (very common)
Ibalgin 400 (very common)
Sertivan (uncommon)

Diarrhea
Lyrica (common)
Ibalgin 400 (common)
Sertivan (uncommon)

Dizziness
Lyrica (very common)
Ibalgin 400 (very common)
Sertivan (uncommon)

Edema
Lyrica (common)
Ibalgin 400 (common)
Sertivan (uncommon)

Flatulence
Lyrica (common)
Ibalgin 400 (very common)
Sertivan (common)

Headache
Lyrica (very common)
Ibalgin 400 (very common)
Sertivan (uncommon)

Nausea
Lyrica (very common)
Ibalgin 400 (very common)
Sertivan (uncommon)

Itching
Lyrica (common)
Ibalgin 400 (uncommon)
Sertivan (common)

Vomiting
Lyrica (common)
Ibalgin 400 (very common)
Sertivan (common)

urinary retention
Lyrica (uncommon)
Ibalgin 400 (common)
Sertivan (common)

edema peripheral
Lyrica (very common)
Ibalgin 400 (uncommon)
Sertivan (uncommon)

Somnolence
Lyrica (very common)
Ibalgin 400 (very common)
Sertivan (uncommon)

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