Drug combination: Sertivan & Lyrica & Tramal & Omeprazol actavis

Compared drugs
Sertivan (sertraline)
Lyrica (pregabalin)
Tramal (tramadol)
Omeprazol actavis (omeprazole)

Drug Interaction

Sertivan & Lyrica
The risk or severity of adverse effects can be increased when Pregabalin is combined with Sertraline.

Sertivan & Tramal
Sertraline may increase the neuroexcitatory activities of Tramadol.

Sertivan & Omeprazol actavis
The metabolism of Sertraline can be decreased when combined with Omeprazole.

Lyrica & Tramal
The therapeutic efficacy of Tramadol can be increased when used in combination with Pregabalin.

Food interactions and other recommendations

Sertivan: Avoid alcohol. Avoid St.John's Wort. Avoid taking with grapefruit juice. Take with food.
Lyrica: Avoid alcohol (may increase CNS effects). When taken with food, Cmax decreases, while Tmax is prolonged. Despite these observations, the total absorption of pregabalin is not effected to a clinically relevant degree. Pregabalin can be taken with or without food.
Tramal: Oral administration of tramadol hydrochloride with food does not significantly affect its rate or extent of absorption, therefore, tramadol hydrochloride can be administered without regard to food.
Omeprazol actavis: Avoid alcohol. Take 30-60 minutes before meals.

Combination of side effects

Combination of common side effects of all medicines

Abdominal Pain
Sertivan (uncommon)
Lyrica (common)
Tramal (uncommon)
Omeprazol actavis (common)

Asthenia
Sertivan (common)
Lyrica (very common)
Tramal (uncommon)
Omeprazol actavis (common)

Constipation
Sertivan (uncommon)
Lyrica (very common)
Tramal (very common)
Omeprazol actavis (common)

Diarrhea
Sertivan (uncommon)
Lyrica (common)
Tramal (common)
Omeprazol actavis (very common)

Dizziness
Sertivan (uncommon)
Lyrica (very common)
Tramal (very common)
Omeprazol actavis (common)

Fatigue
Sertivan (common)
Lyrica (very common)
Tramal (common)
Omeprazol actavis (uncommon)

fever
Sertivan (common)
Lyrica (common)
Tramal (uncommon)
Omeprazol actavis (common)

Flatulence
Sertivan (common)
Lyrica (common)
Tramal (uncommon)
Omeprazol actavis (common)

Headache
Sertivan (uncommon)
Lyrica (very common)
Tramal (very common)
Omeprazol actavis (common)

Nausea
Sertivan (uncommon)
Lyrica (very common)
Tramal (very common)
Omeprazol actavis (common)

paresthesia
Sertivan (common)
Lyrica (common)
Tramal (uncommon)
Omeprazol actavis (uncommon)

Itching
Sertivan (common)
Lyrica (common)
Tramal (common)
Omeprazol actavis (uncommon)

urticaria
Sertivan (common)
Lyrica (uncommon)
Tramal (uncommon)
Omeprazol actavis (uncommon)

vertigo
Sertivan (uncommon)
Lyrica (uncommon)
Tramal (uncommon)
Omeprazol actavis (common)

Vomiting
Sertivan (common)
Lyrica (common)
Tramal (very common)
Omeprazol actavis (common)

Dry mouth
Sertivan (uncommon)
Lyrica (very common)
Tramal (common)
Omeprazol actavis (common)

Malaise
Sertivan (uncommon)
Lyrica (uncommon)
Tramal (uncommon)
Omeprazol actavis (uncommon)

Insomnia
Sertivan (uncommon)
Lyrica (very common)
Tramal (uncommon)
Omeprazol actavis (common)

Somnolence
Sertivan (uncommon)
Lyrica (very common)
Tramal (very common)
Omeprazol actavis (common)

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