Drug combination: Lyrica & Ibalgin 400 & Tramadol aurovitas

Compared drugs
Lyrica (pregabalin)
Ibalgin 400 (ibuprofen)
Tramadol aurovitas (tramadol)
Drug Interaction
Lyrica & Tramadol aurovitas
The therapeutic efficacy of Tramadol can be increased when used in combination with Pregabalin.

Food interactions and other recommendations

Lyrica: Avoid alcohol (may increase CNS effects). When taken with food, Cmax decreases, while Tmax is prolonged. Despite these observations, the total absorption of pregabalin is not effected to a clinically relevant degree. Pregabalin can be taken with or without food.
Ibalgin 400: Avoid alcohol Food delays the time to reach peak plasma concentrations by 30-60 minutes and reduces peak plasma concentrations by 30-50%. Extent of absorption is unaffected. Take with food to reduce gastric irritation.
Tramadol aurovitas: Oral administration of tramadol hydrochloride with food does not significantly affect its rate or extent of absorption, therefore, tramadol hydrochloride can be administered without regard to food.
 
Combination of side effects
Combination of common side effects of all medicines
Anemia
Lyrica (uncommon)
Ibalgin 400 (very common)
Tramadol aurovitas (uncommon)

Constipation
Lyrica (very common)
Ibalgin 400 (very common)
Tramadol aurovitas (very common)

Diarrhea
Lyrica (common)
Ibalgin 400 (common)
Tramadol aurovitas (common)

Dizziness
Lyrica (very common)
Ibalgin 400 (very common)
Tramadol aurovitas (very common)

Flatulence
Lyrica (common)
Ibalgin 400 (very common)
Tramadol aurovitas (uncommon)

Headache
Lyrica (very common)
Ibalgin 400 (very common)
Tramadol aurovitas (very common)

Hematuria
Lyrica (uncommon)
Ibalgin 400 (uncommon)
Tramadol aurovitas (uncommon)

Hypokalemia
Lyrica (uncommon)
Ibalgin 400 (uncommon)
Tramadol aurovitas (uncommon)

Nausea
Lyrica (very common)
Ibalgin 400 (very common)
Tramadol aurovitas (very common)

Itching
Lyrica (common)
Ibalgin 400 (uncommon)
Tramadol aurovitas (common)

Vomiting
Lyrica (common)
Ibalgin 400 (very common)
Tramadol aurovitas (very common)

urinary retention
Lyrica (uncommon)
Ibalgin 400 (common)
Tramadol aurovitas (uncommon)

BUN increased
Lyrica (uncommon)
Ibalgin 400 (uncommon)
Tramadol aurovitas (uncommon)

Somnolence
Lyrica (very common)
Ibalgin 400 (very common)
Tramadol aurovitas (very common)


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