Drug combination: Omnic tocas 0,4 & Rytmonorm & Spiriva respimat & Atoris 20 & Agen 5

Compared drugs
Omnic tocas 0,4 (tamsulosin)
Rytmonorm (propafenone)
Spiriva respimat (tiotropium bromide)
Atoris 20 (atorvastatin)
Agen 5 (amlodipine)
Drug Interaction
Omnic tocas 0,4 & Agen 5
Tamsulosin may increase the hypotensive activities of Amlodipine.

Atoris 20 & Agen 5
The risk or severity of adverse effects can be increased when Amlodipine is combined with Atorvastatin.

Food interactions and other recommendations

Omnic tocas 0,4: Take 30 minutes after a meal (always after the same meal). Taking the drug with food minimizes plasma levels variations.
Rytmonorm: Always take at the same time in regard to meals. Grapefruit and grapefruit juice should be avoided throughout treatment. Grapefruit can increase serum levels of this product.
Atoris 20: Avoid alcohol. Avoid drastic changes in dietary habit. Avoid taking grapefruit or grapefruit juice throughout treatment. Grapefruit can significantly increase serum levels of this product. Food may decrease maximum plasma levels and area under the curve, but this is clinically inconsequential according to the manufacturer. Take with low fat meal.
Agen 5: Avoid natural licorice. Grapefruit down regulates post-translational expression of CYP3A4, the major metabolizing enzyme of amlodipine. Grapefruit, in all forms (e.g. whole fruit, juice and rind), can significantly increase serum levels of amlodipine and may cause toxicity. Avoid grapefruit products while on this medication. Take without regard to meals.
 
Combination of side effects
Combination of common side effects of all medicines
Abdominal Pain
Omnic tocas 0,4 (common)
Rytmonorm (uncommon)
Spiriva respimat (common)
Atoris 20 (common)
Agen 5 (common)


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A freely available non-commercial project for the purpose of laic drug comparisons at the level of interactions, side effects as well as drug prices and their alternatives

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